Immune intelligence startup Serimmune hopes to far better comprehend the romance concerning antibody epitopes (the pieces of antigen molecules that bind to antibodies) and the SARS-CoV-2 virus.
The company’s proprietary technology, initially produced at UC Santa Barbara, delivers a new and specific way of mapping the total array of an individual’s antibodies by a compact blood sample. They do this by the use of a bacterial peptide display—a sort of screening system that can isolate plasmid DNA from antibody-bound bacteria in the sample. This DNA can then be sequenced to detect epitopes, which supply details about both of those which antigens a person may possibly have been uncovered to, as effectively as how his or her immune technique responded to them.
“It’s a pretty highly multiplexed and exquisitely particular way of searching at the epitopes located by antibodies in a specimen,” mentioned Serimmune CEO Noah Nasser, who has a degree in molecular biology from UC San Diego and has previously worked for many diagnostics providers.
This week, Serimmune announced the start of a new application of their core technological know-how to enable understand the illness states of and immune responses to SARS-CoV-2, or the virus that causes COVID-19.
“So what we do is we acquire these antibody profiles we create, and we’re in a position to then map those back again with about a 12 amino acid specificity to the SARS-CoV-2 proteome,” claimed Nasser. “And what we find is that antibody expression is remarkably correlated to disease condition, so we can distinguish mild, moderate, intense and asymptomatic disorder on the foundation of antibodies that are current in the specimen.”
The much more patient details Serimmune can accumulate, the greater its main technology results in being at acquiring patterns throughout distinctive antigen exposure and ailment severity. Noticing people styles sooner will not only assistance medical professionals and researchers to better have an understanding of how the SARS-CoV-2 virus operates, but can also tell new strategies to diagnostics, therapies, and vaccines for any antigen.
Serimmune’s launch of its new COVID antibody epitope mapping assistance is a way of building this facts extra available to customers like vaccine businesses, federal government businesses, and tutorial labs that have revealed interest in better being familiar with the immune response to SARS-CoV-2.
“The crucial was to zero in on the data that researchers wished to know and standardize that,” reported Nasser. “We can essentially now present these results again in as number of as two times from sample receipt.”
Beyond this new services, Serimmune also has ideas to start a longitudinal scientific analyze on immunity to SARS-CoV-2. Applying a painless at-property selection package, analyze participants send in little blood samples to Serimmune, which then utilizes its core technological innovation to outline an specific immunity map.
“We give their outcomes again to them in the form of a personal immune landscape to COVID,” explained Nasser. “And what we’re hoping to do is to fully grasp above time how that immune response variations, and what comes about to that immune reaction on repeated exposure to COVID.”
The mapping know-how is now so distinct that it can explain to whether or not or not a individual has antibodies from purely natural publicity to the SARS-CoV-2 virus or from a vaccine, he added.
Though the main concentration for Serimmune continues to be these apps to the COVID-19 pandemic for now, Nasser also pointed out that the firm has options to move into customized medication, possibly offering their mapping company specifically to interested sufferers.
“We believe that this has worth to personal clients in comprehending their immune status and what antigens they’ve been uncovered to,” he stated. Until eventually then, Serimmune ideas to continue on expanding its databases with additional individual samples.